Probenecid (Benemid)

Category:

  • Antigout agent; uricosuric

Description:

  • Increases urinary excretion of uric acid; inhibits tubular penicillin and most cephalosporin secretion (increasing plasma levels)

Indications:

  • Hyperuricemia associated with gout and gouty arthritis

  • Elevation of plasma penicillin concentrations

  • Elevation of plasma cephalosporin concentrations

Contraindications:

  • Children under age 2

  • Blood dyscrasias

  • Uric acid kidney stones

  • Moderate to severe renal impairment (CrCl <10ml/min)

Precautions:

  • Pregnancy category B

  • History of peptic ulcer

Adverse Reactions (Side Effects):

  • Central Nervous System: dizziness, headache

  • Gastrointestinal: anorexia, nausea, sore gums, vomiting

  • Genitourinary: costovertebral pain, hematuria,mephrotic syndrome, renal colic, uric acid stones, urinary frequency

  • Hematological: Anemia, aplastic anemia, hemolytic anemia

  • Flushing, rash, hypersensitivity reactions  

Dosage:

Oral tablets

  •  Adult:

    • Hyperuricemia:

      • 250mg twice daily for 7 days; increase to 500mg twice daily; increase every 4 weeks as needed to a maximum of 2-3 grams daily.

    • Penicillin or cephalosporin therapy:

      • 500mg four times daily

  • Children: 

    • Penicillin or cepharlosporin therapy:

      • 25mg/kg/day initially; 40mg/kg/day divided four times daily

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300  

Gynecology and Obstetrics CD-ROM
Volumes 1-6
2004 Edition
 Lippincott Williams & Wilkins
Copyright 2004
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