Fig. 34. Photomicrograph showing apoptosis in the granulosa cells of an early tertiary follicle during atresia. Some granulosa exhibit the cytologic features of programmed cell death, including chromatin condensation, blebbing, and release of apoptotic bodies. Some adjacent cells appear healthy. Notice that theca cells do not undergo apoptosis. asterisk, granulosa cells attached to basal lamina have contracted; TI, theca interna; TE, theca externa. (From Sadrkhanloo R, Hofeditz C, Erickson GF: Evidence for widespread atresia in the hypophysectomized estrogen-treated rat. Endocrinology 120:146, 1987, with permission from The Endocrine Society.)