TABLE 2. Partial Recovery of Pituitary Function in a Patient
With Hypothalamic Pituitarism After Treatment With Hydrocortisone
|
|
|
Insulin tolerance test |
ACTH Stimulation test |
Metyrapone test |
TRH Stimulation test |
|
|
|
LHRH Stimulation test |
|
|
|
|
||||
|
|
|
|
|
|
|
|
|
|
Sub- |
|
|
|
|
|
|
|
Plasma |
|
|
|
Time |
Glucose |
GH |
Cortisol |
Time |
Cortisol |
Time |
stance |
FT4I (N |
Time |
TSH |
Pro- lactin |
Time |
FSH |
LH |
|
|
|
Date |
(min) |
(mg/dl) |
(ng/dl) |
(μg/dl) |
(hr) |
(μg/dl) |
(hr) |
S (μg/dl) |
=5–13) |
(min) |
(μU/ml) |
(ng/ml) |
(min) |
(mIu/ml) |
(mIu/ml) |
(pg/ml) |
|
Initial evaluation |
8/78 |
|
|
|
|
0 |
2 |
0 |
1.0 |
|
0 |
6.4 |
2.0 |
0 |
5.4 |
6.4 |
|
|
|
|
|
|
|
|
6 |
12 |
|
|
|
30 |
13.7 |
2.9 |
30 |
6.5 |
15.5 |
|
|
|
|
|
|
|
|
12 |
25 |
|
|
|
60 |
16.2 |
2.8 |
60 |
6.5 |
14.7 |
18 |
|
|
|
|
|
|
|
24 |
25 |
24 |
1.2 |
2.2 |
120 |
18.8 |
2.8 |
120 |
6.5 |
16.3 |
|
|
|
|
|
|
|
|
48 |
30 |
|
|
|
|
|
|
|
|
|
|
|
Treatment with |
10/78 |
|
|
|
|
|
|
|
|
6.8 |
|
|
|
|
|
|
735 |
|
hydrocortisone, 15 mg |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
daily |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Spontaneous menses |
11/78 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Discontinuation of |
1/79 |
0 |
56 |
2.8 |
1 |
|
|
|
|
9.3 |
0 |
4 |
3.1 |
|
|
|
|
|
hydrocortisone |
|
15 |
35 |
3.4 |
1 |
|
|
|
|
|
30 |
7 |
1.9 |
|
|
|
|
|
|
|
30 |
35 |
6.4 |
1 |
|
|
|
|
|
60 |
8 |
2.2 |
|
|
|
|
|
|
|
60 |
119* |
2.2 |
2 |
|
|
|
|
|
120 |
8 |
1.8 |
|
|
|
|
*Fifty percent glucose solution given intravenously because of hypoglycemic
symptoms
ACTH, adrenocorticotropic hormone; TRH, thyrotropin-releasing hormone; LHRH,
luteinizing hormone-releasing hormone; GH, growth hormone; FT4I,
free throxine index; TSH, thyrotropin-stimulating hormone; FSH, follocle-stimulating
hormone; LH, luteinizing hormone