Table 1. Overview of Outcomes of Labor Induction Abortion Methods
Method | Ref | Success 12 hr (%) | Success 24 hr (%) | Success 48 hr | IAT* (hs) | >20 wk | Retained Placenta (%) | Total Curettage (%) | Hemorrhage (%) | Transfusion (%) | Coagulopathy (%) | Cervical Injury (%) | Nausea (%) | Vomiting (%) | Diarrhea (%) | Fever (%) | Infection (%) |
Intra-Amniotic Instillation | |||||||||||||||||
Saline | 8 | 20-00 | 81-000 | 30 | Yes | 32-00 | 1.5-0 | .8-00 | .8-00 | 19-00 | 1-000 | ||||||
Saline + oxytocin | 7,9 | 21–26 | Yes | 13–15 | 2-000 | .5–2- | .3- | .3–4- | 5-000 | 2–3- | |||||||
Saline + PGF2α + oxytocin | 16 | 63-00 | 94-00 | 16.1 | Yes | 24-00 | 2-000 | 2-000 | 1-0 | 0-000 | 48-00 | 33-00 | 1-000 | 3-000 | |||
Urea + oxytocin | 10,11,12 | 97-000 | 19–29 | Yes | 18–19 | 5-000 | .7-00 | .2- | .3–1- | 53-00 | 1-000 | 1-000 | 2–9- | ||||
Urea + PGF2α + oxytocin | 9,10,17 | 85–93 | 12–17 | Yes | 10-00 | 6–10- | .3–2- | 1–3-0 | 73-00 | 5-000 | 6-000 | 5–6- | |||||
Urea + 15-MPGF2α + laminaria | 18 | 97-00 | 13.2 | Yes | 2-000 | 0-000 | .2-00 | 34-00 | 13-00 | 5-00 | |||||||
PGE2 + oxytocin | 13 | 45–54 | 88–90 | 14.5–15.5 | yes | 25-00 | 2-000 | .7-00 | .3-00 | 39-00 | 5-000 | .4-0 | |||||
PGF2α | 8,15 | 54–68 | 82–87- | 19.7 | yes | 41-00 | 3–5-0 | 3-000 | 3-000 | 2-000 | 1–15- | ||||||
PGF2α + oxytocin | 19,20 | 20-00 | 95-00 | 97-000 | 15.6–16.6 | yes | 64-00 | 71-00 | 10-00 | 5–16- | 3-000 | 48–50 | 26–33 | .4-0 | |||
15-MPGF2α | 15 | 72–76 | 93–96- | 18–20 | No | 1–2-0 | 3-000 | 1.5-0 | .5-00 | ||||||||
Extra-Amniotic Administration | |||||||||||||||||
PGE2 + oxytocin | 13,19,20 | 25-00 | 78–90 | 93-000 | 14–17.6 | Yes | 39-00 | 35–42 | 2–10 | 1–10- | 0–.06 | 24–45 | 11–17 | 0-000 | .2–3 | ||
Ethacridine lactate | 22,23 | 69–82 | 99-000 | 15.8 | Yes | 4-000 | 2-000 | 2-0 | 4-000 | 5-00 | |||||||
Vaginal Administration | |||||||||||||||||
PGE2 | 24,25,26,27,28,29,30 | 50-00 | 86–93 | 13 | Yes | 42-00 | 21–68 | 0–2-0 | 2-000 | 46–62 | 30–54 | 15–40 | 20–64 | 1-00 | |||
Gemeprost | 31,32,33,34 | 74–88 | 92–100 | 14.5–19.3 | No | 20–54 | 64–78 | 1–2-0 | 1–4-0 | .1–2- | 14–23 | 20–26 | 14–18 | .1-0 | |||
Misoprostol | 29,35,39,42,46 | 59–89 | 60–100 | 12–28 | Yes | 8–57- | 0-000 | 0-000 | 28–37 | 4–28- | 2–14- | 8–11- | 0-00 | ||||
Mifepristone (mife) Regimens | |||||||||||||||||
Mife 200 mg + gemeprost | 57,59 | 88–98 | 99–100 | 7.5–10.8 | Yes | 24-00 | 18–40 | 0–1-0 | 1-000 | 44-00 | 16–44 | 4–44- | |||||
Mife 200 mg + vaginal miso | 59,60,61,63 | 82–88 | 84–97 | 100-00 | 6.0–10.0 | No | 9-000 | 11–25 | 3-000 | 0-000 | 32-00 | 52–61 | 25–56 | 12-00 | |||
High-Dose Oxytocin | |||||||||||||||||
Oxytocin | 24, 25 | 80–91 | 8.2–12.6 | Yes | 33-00 | 18-00 | 0-000 | 0-000 |