Chapter 47
Male Sterilization
Amy E. Pollack and Mark A. Barone
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Amy E. Pollack, MD, MPH
President, AVSC International, New York, New York (Vol 6, Chaps 47, 48, 49)

Mark A. Barone, DVM, MS
AVSC International, New York, New York (Vol 6, Chaps 47, 48, 49)

INTRODUCTION
HISTORY
ANATOMY
COUNSELING FOR VASECTOMY
DOCUMENTING INFORMED CONSENT
PREOPERATIVE SCREENING AND EVALUATION
GENITAL EXAMINATION
PENILE EXAMINATION
SCROTAL EXAMINATION
PALPATION OF THE TESTIS AND EPIDIDYMIS
PALPATION OF THE SPERMATIC CORD AND VAS DEFERENS
PRECAUTIONS
VERIFYING INFORMED CONSENT
TECHNIQUES
POSTOPERATIVE CARE AND INSTRUCTIONS
INTRAOPERATIVE AND IMMEDIATE COMPLICATIONS
SEMEN ANALYSIS AND CLEARANCE
EFFICACY
REGRET
REFERENCES

INTRODUCTION

Vasectomy is now well recognized worldwide as one of the safest and most effective contraceptive methods. It is estimated that more than 42 million men are currently vasectomized.1 Although most are concentrated in a small number of countries, the distribution of users is becoming increasingly widespread. In comparison, an estimated 150 million women have been sterilized worldwide; however, in several countries, vasectomy incidence approaches that of female sterilization. In 1995, an estimated 494,000 vasectomies were performed in the United States, for a rate of 9.9 procedures per 1000 men aged 25 to 49 years,2 compared with 693,000 tubal sterilizations, for a rate of 11.7 per 1000 women aged 20 to 49 years.3

Some predicted that men would not accept the vasectomy procedure because they fear loss of masculinity or because they mistakenly equate vasectomy with castration. However, when vasectomy is properly presented, men in all societies can welcome the procedure. Several conditions appear to be of critical importance. Men's desire to limit family size and their concern for economic and educational advancement must outweigh their desire for more children, and their concerns about maternal morbidity and the failure of female contraceptive methods must be an overriding consideration.

Most couples seeking vasectomy are dissatisfied users of other forms of contraception. Many couples find barrier methods inconvenient. Women using hormonal methods may have suffered from related side-effects or experienced user difficulties such as limited access to pill supplies or trained providers for implants. Intra-uterine devices also have associated side-effects.

As is true with many other contraceptive methods in which popularity and acceptance preceded thorough scientific understanding of effects on body systems and long-term sequelae, the effects of vasectomy have come under scrutiny by investigators. In the past 20 years, immunologic response and effects on lipid metabolism, spermatogenesis, epididymal function, and hormone levels have been studied. Long-term complications following vasectomy, including increased risk for heart disease, testicular cancer, immune complex disorders, and a host of other conditions, have not been supported by long-term, well-designed epidemiologic studies. The relation between vasectomy and prostate cancer has been studied intensely and, taken as a whole, these studies provide little evidence for a causal association between vasectomy and prostate cancer.

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HISTORY

The clinical use of vasectomy is historically linked with the course of experimental investigation. The first reference to the occluded vas was made by Hunter during his dissections in 1775. The first experiment in tying of the vas was reported as early as 1785, but it was not until the 19th century that several investigations into the effects of vasectomy were undertaken. In 1830, Cooper initiated the first systematic experimental work when he demonstrated that closing the duct of the testis had no effect on the production of sperm by the testis for as long as 6 years after the operation. In 1921, Simmonds noted that even in cases in which the vasa deferentia had been occluded for many years, there was no apparent injury to the sperm-producing functions of the testicles. Gosselin confirmed this finding in 1947.

In the late 1890s, an investigation of the clinical uses of vasectomy was begun by surgeons in conjunction with therapeutic operations on the prostate gland. Ochsner performed such operations and reported that no change was noted in the sexual function of his patients following successful vasectomies.

In the 1920s, Rolnick studied the regenerative power of the vas and its ability to resist trauma and restore continuity of its lumen. He emphasized the importance of the blood supply and the sheath of the vas acting as a splint making a path of epithelialization during recanalization and after vas ligation. This classic work still has pertinence today in our efforts to achieve successful vas occlusion and to reduce the chance of failure, and informs us about the potential for successful vasectomy reversal when indicated.

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ANATOMY

The male reproductive organs include the testicles, the ducts, and the accessory glands (Fig. 1). The testicles produce sperm and the male sex hormone testosterone. After vasectomy, the testes continue to produce both sperm and hormones.

Fig. 1. Male reproductive organs.(From AVSC International. No-Scalpel Vasectomy Curriculum. New York, AVSC International, 1997.)

The second group of organs is a series of connected ducts: the epididymides, the vasa deferentia, and the urethra. Each of the two epididymides (which begin at and are connected to the testes) are connected to one of the vasa deferentia. Sperm pass through the epididymis to get from the testis to the vas and are also stored in the most distal portion, or tail, of the epididymis. Sperm become motile and acquire the ability to fertilize ova during transport through the epididymides. The vasa begin at the epididymides and end at the base of the prostate, where they come together and are connected to the urethra and the accessory glands. Here, the sperm, which were carried by the vasa deferentia, mix with secretions from the accessory glands. The urethra carries the semen (i.e. sperm contained in the secretions from the accessory glands) out of the body during ejaculation. The urethra also carries urine.

The third group of internal organs are the accessory glands. These include the seminal vesicles, the prostate, and the bulbourethral glands. These glands secrete the seminal fluid that carries sperm through the urethra during ejaculation.

The vas deferens is a firm, tubular structure approximately 3 to 4 mm in diameter and approximately 35 cm in length. It extends from the tail of the epididymis to the prostate, where, together with the duct of the seminal vesicle, it forms the ejaculatory duct.

The vas deferens may be divided into five portions: the sheathless epididymal vas, the scrotal vas, the inguinal vas, the retroperitoneal or pelvic vas, and the ampulla (Fig. 2). The portion of the vas of clinical interest in relation to vasectomy is the scrotal vas in the midscrotal area. Here the vas is located within the spermatic cord, which is made up of fascia, arteries, veins, and nerves and which suspends the testis in the scrotum (Fig. 3). The firm, thick structure of the vas can be easily palpated and differentiated from other structures in the spermatic cord. Also in the spermatic cord is the testicular artery, which supplies blood to the testis and epididymis, and the testicular veins, which form the pampiniform plexus that returns blood from the testis and epididymis.

Fig. 2. Anatomy of the vas.(Copyright AVSC International, 1999.)

Fig. 3. Cross-section of the spermatic cord.(From AVSC International. No-Scalpel Vasectomy Curriculum. New York, AVSC International, 1997.)

The vas deferens is composed of three layers of smooth muscle: the outer and inner longitudinal layers and the middle circular layer. It is capable of powerful peristaltic motion. There is a thick sheet of connective tissue exterior to the muscle layer. The lumen of the vas, like that of the epididymis, is lined with pseudostratified epithelium and contains longitudinal folds lined with microvilli.

The blood supply of the vas deferens is from the artery of the vas deferens (deferential artery), a branch of the superior vesical artery that is also important in collateral circulation for the testicle. This artery is easily separated from the vas during vasectomy; however, it may be a source of hemorrhage during vasectomy if it is not separated or ligated.

The nerves of the testes (the superior spermatic nerves) arise from the renal plexus and intermesenteric nerves and travel in association with the testicular arteries, whereas the inferior spermatic nerves arise from the hypogastric plexus and course around and along the vas deferens to innervate the epididymides. At the junction of the epididymis and vas deferens, the amount of adrenergic innervation increases, with innervation of the vas consisting of short, postganglionic neurons.4 Adrenergic fibers, which are found in all three smooth muscle layers, are most likely the motor supply of the vas muscle. The sheath of the vas in the scrotal portion contains pain nerves. Careful infiltration of the sheath with local anesthetic agents is effective in reducing pain during the procedure.

Blood vessels and nerves involved in erection and ejaculation, including the internal pudendal artery, dorsal and cavernous veins, pudendal nerves (sensory nerves to the penis), and nerves from the pelvic plexus arising from sacral nerves S2-S4 (nerves involved in erection), are located well away from the procedure site and are therefore unaffected by vasectomy.

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COUNSELING FOR VASECTOMY

The patient's request for vasectomy must be made voluntarily. Good counseling for men interested in vasectomy is critical for two reasons: vasectomy is permanent, and vasectomy is a surgical procedure that carries with it the risks inherent in any surgery. Because men's greatest fears about vasectomy are related to pain of the procedure, impact on sexual functioning, and potential for adverse effects,5 these topics should be thoroughly covered during counseling. Counseling should involve both partners if possible and include the following steps6,7,8:

  1. Discuss vasectomy in conjunction with an explanation of all other available contraceptive options.
  2. Discuss the patient's readiness to end his fertility and screen for indicators of poststerilization regret. Factors shown to predispose to poststerilization regret include young age (less than 31 years), quick or economically motivated decision or decision related to pregnancy, marital instability, and no children or children very young at the time of sterilization.9,10,11 The provider should explore with the individual whether he would feel differently if his marital situation changed or if he lost his spouse or a child. Identifying regret risks should not be a reason for denying vasectomy but should be an indicator that more careful counseling and discussion of other contraceptive methods are necessary.
  3. Emphasize that vasectomy should be regarded as a permanent procedure, and inform the client of failure rates associated with vasectomy. Despite what the client may have heard about vasectomy reversal, it is expensive, and success cannot be guaranteed. If a client considering vasectomy is seriously thinking about reversal, a vasectomy may not be the best procedure for him at this time. Likewise, if a man asks to have his sperm stored in a sperm bank for the future, mention to him that this is costly and viable long-term storage is not without risk and that he may want to reconsider vasectomy.
  4. Using diagrams, briefly describe the vasectomy procedure and how a vasectomy works. Describe to the patient the surgical site, time the procedure usually takes, type of anesthesia, length of recovery, and resumption of sexual activity. Discuss general surgical risks. Emphasize that vasectomy is not effective immediately and that the client should use an alternate method of contraception until his semen is tested and found to be free of sperm.
  5. Describe all medical benefits and risks. Fears and myths regarding the long-term health effects of vasectomy often lead to eventual dissatisfaction with the procedure. Although the body of research suggests that vasectomized men are no more likely than nonvasectomized men to develop heart disease and cancer, preventive lifestyle and screening should be addressed. Emphasize that vasectomy provides no protection against sexually transmitted diseases, including human immunodeficiency virus (HIV) infection.
  6. Point out that vasectomy does not cause a loss in physical strength, development of a high pitched voice, a loss or change in sexual function, weight gain, or a loss of masculinity. Inform the client that he will still ejaculate after surgery and in the same amount. The semen will not, however, contain any sperm after successful vasectomy. Some studies have indicated that sexuality may improve because couples do not worry about accidental pregnancy.
  7. Tell the patient about any fees he is expected to pay. Ensure compliance with local, state, and institutional restrictions regarding age, waiting periods, and second opinions.

Throughout the discussion, answer client questions and concerns. Use diagrams and pictures of instruments to reduce patient anxiety. Emphasize that vasectomy is a safe, moderately priced, simple, and highly effective procedure.

Provide printed educational materials that the client and his partner can review privately, as well as oral and written preoperative instructions. Preoperative vasectomy patients must avoid aspirincontaining drugs for 2 weeks before and 1 week after surgery.8 The client must also undergo a limited physical examination; in specific cases, laboratory workup is required (blood count, bleeding and clotting time, urinalysis, and semen analysis), but this is not routinely done. On the day of surgery, the client should bathe or shower and wear loose-fitting clothing. If necessary, hair on the scrotum should be clipped immediately before the procedure and not by the client at home. The client should bring an athletic supporter or briefs to wear after the surgery.

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DOCUMENTING INFORMED CONSENT

The client signs an informed consent form on the day of surgery to indicate that he has reviewed the information given him and discussed his decision with the vasectomy provider. The client must understand the six points of informed consent listed below and know what he is signing. The provider should encourage the client to ask questions. The six points of informed consent are12:

  1. Temporary contraceptive methods are available to the client and his partner.
  2. Vasectomy is a surgical procedure.
  3. There are certain risks associated with vasectomy, as well as benefits, both of which must be explained.
  4. If successful, vasectomy will prevent the client from having any more children.
  5. The effect of vasectomy is to be considered permanent.
  6. The client can decide against the operation at any time before the procedure without losing the right to other medical, health, or other services or benefits.

With a witness present, the client's signature or mark should be obtained. If the client is illiterate, the provider should obtain a witness's signature attesting that the client has affixed his mark or thumbprint on the informed consent form.

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PREOPERATIVE SCREENING AND EVALUATION

There should be no rigid guidelines concerning waiting periods between the prevasectomy medical history and physical examination and the performance of the vasectomy. Generally, a 2- to 3-week period gives the client or couple sufficient time to consider any possible concerns about effects on sexuality or health. Table 1 lists the required and recommended components of a prevasectomy medical history and physical examination and explains the reason each component is included.

TABLE 1. Components of a Prevasectomy Medical History and Physical Examination


Component

Reason

Medical History

 

Existence of bleeding disorders

Can indicate the potential for hemorrhage

Previous scrotal or inguinal

Scarring or adhesions that could complicate a

 surgery or trauma

 vasectomy procedure may exist

Current or past genitourinary

Past infections could have caused scarring and

 infections, including sexually

 adhesions; current infection could lead to acute

 transmitted diseases

 postvasectomy infection

History of sexual impairment

Can indicate preexisting psychological or physio-

 

 logic problems that could later be incorrectly

 

 attributed to the vasectomy

Current and recent medications

Can indicate medical problems that the vasectomist

 

 should be aware of before surgery

Allergy to medications

Can help prevent complications by determining

 

 whether the client has ever had an allergic reaction

 

 to any of the medications or antiseptics used

 

 before, during, or after surgery

Physical Examination

 

Genitals

Can rule out the presence of infections or masses

 

 that the vasectomist should be aware of before

 

 surgery

Lungsa (auscultation and respira-

Can rule out infections and other lung disease that

 tory rate)

 the vasectomist should be aware of before surgery

Abdomena (palpation)

Can rule out the presence of infections, organ

 

 enlargements, or masses that the vasectomist

 

 should be aware of before surgery

Hearta (auscultation, pulse, and

Can rule out hypertension, heart murmurs, and

 blood pressure)

 other cardiovascular disease that the vasectomist

 

 should be aware of before surgery


a Recommended but not essential.
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GENITAL EXAMINATION

After the client's heart, lungs, and abdomen have been examined, a genital examination should be performed. Before beginning the examination, the surgeon should tell the client what will be done and why it is done. The man is assured that he will feel minimal pain. During the genital examination, penile and scrotal examination is conducted. Unless lesions are observed, gloves are unnecessary during a genital examination, but the doctor should wash his or her hands thoroughly before and after the examination.

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PENILE EXAMINATION

Visual Inspection

The penis is visually inspected, and any lesions or scarring are noted. The penis, including the underside, is gently lifted and examined. The urethral opening is examined. Any abnormalities such as discharge, reddening, or irritation are noted and assessed.

Potential Abnormalities

Potential abnormalities include rash, cyst, discharge, and skin cancer (rare).

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SCROTAL EXAMINATION

Visual Inspection

The scrotal skin is visually inspected. The scrotum is lifted to examine the posterior side. Coloring, size, and contour are observed. Any swelling or masses are noted and assessed.

Potential Abnormalities

Potential abnormalities include rash, cysts, poorly developed scrotum (possible cryptorchidism), and swelling (possible inguinal hernia, torsion of spermatic cord, strangulated inguinal hernia).

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PALPATION OF THE TESTIS AND EPIDIDYMIS

Using the thumb and first two fingers, the doctor palpates each testis and epididymis (Fig. 4). He or she avoids putting pressure on the testis during the palpation so as not to cause pain. The size, shape, and consistency of each testis and epididymis are noted. Any nodules or tenderness are noted.

Fig. 4. Palpation of the testis and epididymis.(From AVSC International. No-Scalpel Vasectomy Curriculum. New York, AVSC International, 1997.)

Potential Abnormalities

Painless nodules in the testes may indicate testicular cancer. Nodules in the epididymis may indicate an epididymal cyst (seminoma).

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PALPATION OF THE SPERMATIC CORD AND VAS DEFERENS

Each spermatic cord and its vas deferens are palpated (Fig. 5). The doctor moves his or her thumb and fingers along its length. Any nodules or swellings are noted.

Fig. 5. Palpation of the spermatic cord and vas deferens.(From AVSC International. No-Scalpel Vasectomy Curriculum. New York, AVSC International, 1997.)

Potential Abnormalities

Potential abnormalities include thickened vas (suggests chronic infection), tortuous veins (suggests varicocele), and cyst in the cord (suggests hydrocele).

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PRECAUTIONS

Although vasectomy is a simple operation that can be performed almost anywhere, the more removed the setting is from medical back-up, the more important it is to screen out men who are likely to develop complications.

The major physical precautions to performing vasectomy are local skin infection and systemic blood disorder. Local skin infection, which can prevent normal healing or increase risk of postoperative infections, is easily recognized and should be treated and the condition resolved before the operation is performed. Other local conditions that make vasectomy more difficult to perform include inguinal hernia, previous surgery for hernia or orchiopexy, hydrocele, varicocele, preexisting scrotal lesions, and a thick, tough scrotum.

Systemic blood disorders that call for special precautions include any disease that interferes with normal blood clotting (e.g. hemophilia). In such cases, the vasectomy technique used should minimize tissue trauma, and emergency equipment should be available. If the patient is taking anticoagulants, the same precautions may be required. Other systemic diseases, such as diabetes, hypertension, or other cardiac disease, are not contraindications to vasectomy, but hospitalization and intraoperative monitoring with prolonged close observation and follow-up are advisable in case emergencies arise. Table 2 presents the World Health Organization's eligibility criteria for vasectomy procedures,13 which include standard vasectomy precautions.

TABLE 2. WHO Eligibility Criteria for Vasectomy Procedures


There is no medical reason that would absolutely restrict a person's eligibility for steril-ization. There may be conditions and circumstances that indicate that certain precautions should be taken.

The classification of the conditions into the different categories is based on an in-depth review of the epidemiologic and clinical evidence relevant to medical eligibility.

Definitions

 

A (Accept):

There is no medical reason to deny sterilization to a person with this

 

 condition.

C (Caution):

The procedure is normally conducted in a routine setting, but with extra

 

 preparation and precautions.

D (Delay):

The procedure is delayed until the condition is evaluated and/or corrected.

 

 Alternative temporary methods of contraception should be provided.

S (Special):

The procedure should be undertaken in a setting with an experienced

 

 surgeon and staff, equipment needed to provide general anesthesia, and

 

 other back-up medical support. For these conditions, the capacity to decide

 

 on the most appropriate procedure and anesthesia regimen is also needed.

 

 Alternative temporary methods of contraception sould be provided if referral

 

 is required or there is otherwise any delay.

Condition

Category

Rationale/Comments

Local infections (scrotal

D

There is an increased risk of

 skin infection, active

 

 postoperative infection.a

 STD, balanitis,

 

 

 epididymitis or orchitis)

 

 

Previous scrotal injury

C

 

Systemic infection or

D

There is an increased risk of

 gastroenteritis

 

 postoperative infection.a

Large varicocele

C

The vas may be difficult or impossible

 

 

 to locate; a single procedure to repair

 

 

 varicocele and perform a vasectomy

 

 

 decreases the risk of complications.

Large hydrocele

C

The vas may be difficult or impossible to

 

 

 locate; a single procedure decreases

 

 

 the risk of complications.

Filariasis; elephantiasis

D

The scrotum may be involved in severe

 

 

 elephantiasis making it impossible to

 

 

 palpate the cord structure and testis.

Intrascrotal mass

D

This may indicate an underlying

 

 

 disease.

Cryptorchidism

C

If cryptorchidism is bilateral, and fertility

 

 

 has been demonstrated, this will require

 

 

 extensive surgery to locate the vas,

 

 

 making the condition category S. If

 

 

 cryptorchidism is unilateral and fertility

 

 

 has been demonstrated, vasectomy

 

 

 may be performed on the normal side

 

 

 and the spermogram checked, as per

 

 

 routine. If sperm continue to be

 

 

 persistently present, more extensive

 

 

 surgery may be required to locate the

 

 

 other vas, and the condition becomes

 

 

 category S.

Inguinal hernia

S

Vasectomy can be performed

 

 

 concurrent with hernia repair.

Sickle cell disease

A

 

Coagulation disorders

S

Bleeding disorders lead to an increased

 

 

 risk of postoperative hematoma

 

 

 formation which, in turn, leads to an

 

 

 increased risk of infection.

Diabetes

C

Diabetics are more likely to get post-

 

 

 operative wound infections. If signs

 

 

 of infection appear, treatment with

 

 

 antibiotics needs to be given.

HIV/AIDS

 

 

HIV-positive

A

Proper infection prevention procedures

High risk of HIV

A

 must be followed. If the man is currently

AIDS

S

 suffering an AIDS-related illness, the

 

 

 procedure should be performed in an

 

 

 appropriate setting.


a Cohn I, Bornside GH. Infections. In Schwartz SI, Shires GT, Spencer FC (eds.). Principles of Surgery, 5th ed. New York: McGraw-Hill Book Co., 1989:181–215.
(Adapted from World Health Organization (WHO). Improving Access to Quality Care in Family Planning: Medical Eligibility Criteria for Contraceptive Use. Geneva: WHO, 1996)
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VERIFYING INFORMED CONSENT

Just prior to surgery, the surgeon should verify that the patient has signed an informed consent form. The guide presented in Figure 6 can be used in making a final assessment of the patient's informed decision to have a vasectomy.

Fig. 6. Assessing a client's decision for vasectomy.(From AVSC International. No-Scalpel Vasectomy Curriculum. New York, AVSC International, 1997.)

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TECHNIQUES

Approaches to the Vas

Conventional vasectomy is performed under local anesthesia. A scalpel is used to make either one midline incision or two incisions overlying each vas deferens; these incision or incisions are 1 to 2 cm long (Fig. 7). After occlusion of the vasa using the surgeon's preferred technique, the incision or incisions are closed with sutures.

Fig. 7. Conventional vasectomy technique.(Copyright AVSC International, 1999.)

No-scalpel vasectomy is a method of delivering the vasa deferentia under local anesthesia that was developed and has been used in China since 1974.14,15 It has been introduced in many developed and developing countries. This technique eliminates the need for use of a scalpel and instead utilizes two specialized instruments: a ringed clamp (Fig. 8) and dissecting forceps (Fig. 9). No-scalpel vasectomy involves a deep injection of local anesthetic applied alongside each vas, creating a vasal nerve block (Fig. 10). In conventional vasectomy techniques, only the area around the skin entry site is anesthetized.

Fig. 8. Ringed clamp used for no-scalpel vasectomy.(From AVSC International. No-Scalpel Vasectomy: An Illustrated Guide for Surgeons, 2nd ed. New York, AVSC International, 1997.)

Fig. 9. Dissecting forceps used for no-scalpel vasectomy.(From AVSC International. No-Scalpel Vasectomy: An Illustrated Guide for Surgeons, 2nd ed. New York, AVSC International, 1997.)

Fig. 10. Creating the vasal nerve block.(From AVSC International. No-Scalpel Vasectomy: An Illustrated Guide for Surgeons, 2nd ed. New York, AVSC International, 1997.)

The ringed clamp encircles and firmly secures the vas without penetrating the skin (Fig. 11). A sharp, curved hemostat (the dissecting forceps) punctures and spreads the scrotal skin and vas sheath. The vas is delivered, cleaned, and occluded using the surgeon's preferred technique (Fig. 12). The contralateral vas is then delivered through the same opening and occluded. The puncture wound contracts to about 2 mm, is not visible to the client, and requires no sutures for closure.

Fig. 11. The tissues are spread to make a skin opening twice the diameter of the vas.(From AVSC International. No-Scalpel Vasectomy: An Illustrated Guide for Surgeons, 2nd ed. New York, AVSC International, 1997.)

Fig. 12. The ringed clamp is released before elevating the vas with the dissecting forceps. The ringed clamp is open but still in place.(From AVSC International. No-Scalpel Vasectomy: An Illustrated Guide for Surgeons, 2nd ed. New York, AVSC International, 1997.)

No-scalpel vasectomy offers several advantages over conventional vasectomy. No-scalpel vasectomy results in fewer hematomas and infections compared with conventional vasectomy (Table 3).

TABLE 3. Incidence of Infection and Hematoma or Bleeding After Vasectomy


 

No. of

Infections

Hematoma or

Reference

Subjects

(%)

Bleeding (%)

Incisional

 

 

 

Philp et al 198416

534

1.3

4.5

Kendrick et al 198717

65, 155

3.5

2.0

Nirapathpongporn et al 199018

523

1.3

1.7

Alderman 199119

1224

4.0

0.3

Sokal et al 199920

627

1.3

10.7

No-Scalpel

 

 

 

Nirapathpongporn et al 199018

680

0.2

0.3

Li et al 199114

179, 741

0.9

0.1

Li et al 199114

238

0

0

Sokal et al 199920

606

0.2

1.7

Arellano et al 199721

1000

0

2.1

In a 1991 survey conducted in the United States, 78 out of 111 surgeons (70%) said they believed patients undergoing no-scalpel vasectomy with vasal block anesthesia experienced less operative pain than did patients undergoing conventional vasectomy.15 Indeed, men undergoing no-scalpel vasectomy reported less pain during the procedure and early follow-up period, and also reported earlier resumption of sexual activity after surgery.20,22 Because there is no scrotal incision, no-scalpel vasectomy is believed to decrease men's fears regarding vasectomy.15

Neither conventional nor no-scalpel vasectomy is time consuming; however, there are reports of decreased operating time when skilled providers use the no-scalpel approach. For example, a study in Thailand showed that surgeons who used the no-scalpel technique were able to perform an average of 57 procedures per day, whereas those using the conventional technique performed an average of 33 procedures per day.18 Similarly, in the United States, a 40% reduction in operating time has been reported with no-scalpel vasectomy.14

Occlusion of the Vas Deferens

A variety of methods are currently used for occlusion of the vas, including ligation with sutures, division, cautery, clips, excision of a segment of the vas, and combinations thereof. Simple ligation without division and simple division alone are not recommended, because the potential for failure due to recanalization is high. There is little consensus regarding what occlusion technique is best. In the United States, for example, results of a recent survey indicated that occlusion technique varied: 38% of vasectomies were performed using ligation and cautery, 18% using ligation only, 18% using cautery only, 15% using cautery and clips, 9% using clips only, and 2% using ligation and clips.2

This lack of consensus is partially due to the fact that good research data are unavailable to support the use of any one technique over another. Most reports in the literature are retrospective reviews of individual physicians' experiences of either a single occlusion method or sequential use of two methods. It is difficult to interpret some studies because details on definitions of failure, follow-up protocols, loss to follow-up rates, or statistical methods are often lacking. Although these factors also contribute to the difficulty in comparing results among studies, the fact that most studies use a different occlusion technique—ligation, clips, cautery, excision versus no excision, closed versus open, fascial interposition versus no fascial interposition, or different combinations of the various technique— makes most comparisons across studies questionable. Often, however, individual surgeons have their own preferences regarding occlusion method.

Similarly, there is little information on the relation of the length of vas removed and the success of the procedure. Hallan and May23 determined that 7 cm of vas had to be removed to alleviate the possibility of a sperm granuloma bridging the gap between the cut ends of the vas. Although most surgeons remove a segment of the vas, some investigators report success using division and occlusion of the vas without removal of any vas tissue itself.8,24–26

Routine referral of the vas for pathologic study is neither essential nor recommended. The presence of two vas specimens does not substitute for determining the endpoint of azoospermia. Because the same vas may have been sectioned twice or a double vas may be present, the patient may still be fertile despite the fact that two separate specimens have been sent to the laboratory. Conversely, even if the laboratory cannot confirm the presence of vasa on microscopic examination, the patient may still have a successful procedure, because tissue can be distorted in removal or lost in transit to the laboratory.

Open-ended vasectomy (i.e. not sealing the testicular end of the cut vas) has been examined as a way of increasing the likelihood of success if subsequent reversal is requested. There is some evidence that open-ended vasectomy leads to reduced pressure-induced damage of the epididymis.27 Published studies vary; some report low failure rates comparable to those usually reported for closed-ended vasectomy techniques,26,28,29 and others report higher failure rates with the open-ended technique.30,31,32 Open-ended vasectomy is not commonly practiced.

Fascial interposition, or suturing the spermatic fascia over one end of the vas to place a tissue barrier between the two cut ends, has been theorized as a way to reduce the potential for recanalization. Although some investigators have reported good results with this technique,24,33,34 others have reported low and comparable failure rates when fascial interposition is not used.16,35 Results from randomized clinical trials comparing no fascial interposition with fascial interposition have not been reported. In the United States, 48% of physicians reported they use fascial interposition when performing vasectomies.2

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POSTOPERATIVE CARE AND INSTRUCTIONS

Men who have undergone vasectomy may leave the health facility after resting for 30 minutes. If the patient has been sedated, his vital signs should be monitored every 15 minutes until stable; he then can be released. Information should be provided in simple language to the patient regarding how to care for the wound, what side effects to expect, what to do if complications occur, where to go or who to call for emergency care, and where and when to return for a follow-up visit. The patient should be informed that minor pain and bruising are common and do not require medical attention. However, if he develops a fever, if blood or pus oozes from the vasectomy site, or if excessive pain, swelling, or bruising occurs, he should seek medical care. Written postvasectomy instructions should be provided (Fig. 13).

Fig. 13. Sample postoperative instructions for the client.

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INTRAOPERATIVE AND IMMEDIATE COMPLICATIONS

Vasectomy is considered a minor and safe surgical procedure; complications are rare. Intraoperative complications may include vasovagal reaction and lidocaine toxicity. Table 4 provides information on management of intraoperative complications.

TABLE 4. Potential Intraoperative Complications of Vasectomy


 

Vasovagal Reaction

 

 

(Neurocardiogenic Syncope)

Lidocaine Toxicity

Symptoms

Fainting

Numbness of tongue and mouth

 

Nausea

Lightheadedness

 

Weakness

Tinnitus (ringing in the ears)

 

Lightheadedness

Visual disturbances

 

Blurred vision

Slurred speech

 

Sweating

Respiratory depression

 

Decreased blood pressure

Respiratory arrest

 

Heart rate increases initially,

 

 

 then decreases

Myocardial depression

 

Pallor

Arrhythmia

 

Cold, clammy hands

Hypotension

 

Restlessness

Cardiac arrest

 

 

Convulsions

 

 

Coma (very high overdose)

Treatment

Reassure the client

Drug discontinuation

 

Raise the client's feet

General supportive measures

 

Lower the client's head

Maintain airway and respiration

 

Administer atropine if the client's

Oxygen

 

 pulse is lower than 40 bpm

Diazepam or thiopental

 

Administer oxygen

 (for convulsions)

 

 

Vasopressors (e.g. norepinephrine

 

 

 or dopamine) for hypotension

Etiology

Painful procedure

Overdose of lidocaine

 

Anxious client

Intravascular injection

Prevention

Gentle surgical technique

Do not administer a dose >20 ml

 

Effective anesthetic block

 of 1% solution or >10 ml of 2%

 

Explain procedure to the client in advance

 solution

 

Reassure client during procedure

 

Immediate postoperative complications of vasectomy include bleeding, hematoma, and infection. Hematomas occur in approximately 2% of men; however, a wide range of rates have been reported, from less than 1% to nearly 30%.17 Studies consistently suggest that the incidence of hematoma is directly proportional to surgical skill and experience with the vasectomy procedure. In a large U.S.-based survey among providers of conventional vasectomy (including urologists, family physicians, and general surgeons), the mean hematoma rate was significantly higher among physicians performing 1 to 10 vasectomies per year (4.6%) than among those performing 11 to 50 vasectomies per year (2.4%) or more than 50 vasectomies per year (1.6%).17 The corresponding incidences of hospitalization were 0.8%, 0.3%, and 0.2%, respectively.

Most infections are minor, and an average incidence of 3.5% was reported in one series of more than 65,000 vasectomies.17 Higher rates of infection have also been reported.36–38 The incidence of infection has not been shown to vary by surgeon's experience.17

Rates of immediate complications also vary depending on the approach to the vas, with no-scalpel vasectomy consistently resulting in lower hematoma and infection rates than conventional vasectomy (see Table 3).

No association has been documented between use of general anesthesia or the setting where vasectomies were performed and any complication.17

Another early complication is sperm granuloma formation. Sperm that leak from the end of the cut vas may induce an inflammatory reaction leading to the formation of sperm granuloma. Sperm granulomas are seen in 15% to 40% of men presenting for vasectomy reversal.39,40 Only approximately 2% to 3% of these are painful or in some way symptomatic; such symptoms peak at the second or third postoperative week.17,39,41 Discomfort can be treated symptomatically with anti-inflammatory drugs. Open-ended vasectomy has been reported to decrease the occurrence of sperm granulomas.26,28,29

Providers can prevent most complications by paying attention to hemostasis, practicing good aseptic technique, and minimizing tissue trauma during vasectomy procedures. Table 5 provides information on prevention and treatment of complications of vasectomy.

TABLE 5. Potential Postoperative Complications of Vasectomy


 

Symptoms

Treatment

Prevention

Etiology

Bleeding

Bleeding observed at incision site

Most small vessel bleeding can be controlled by compression

Careful surgical technique vessels from the vas before transection

Vasectomist's failure to strip spermatic cord

 

Swelling of scrotum

Cautery and ligature may be used for large vessel bleeding

Vasectomist's failure to control bleeding before wound closure

 

Hematoma

Swelling of scrotum

Control bleeding by pressure

Careful surgical technique

Rough handling of tissue

 

 

Cautery and ligature may be used for large vessel bleeding

Understanding and carrying out of postvasectomy instructions heavy lifting by client after vasectomy

Vasectomist's failure to control bleeding before wound closure

 

 

Rarely, may require incision and drainage

Client's failure to wear snug undergarments after vasectomy

Excessive strain or

 

 

If hematoma is stable, allow to resolve on its own

Client's failure to rest

 

 

 

Provide prophylactic antibiotics for 24 hours after vastectomy

 

 

Infection

Pus, swelling, or pain at the incision site or in the scrotum

Superficial infections: clean and apply local antiseptic and clean dressing

Observance of proper infection prevention procedures

Failure by vasectomist to follow infection prevention procedures

 

Fever

Underlying tissue infection: antibiotics and wound care

Recognition of bleeding

Improper postoperative care of the wound by vastectomy

 

 

Abscess: antibiotics, drainage and wound care

Client keeps wound dry after vasectomy mist or client

 

 

 

Cellulitis or fascitis: debridement, antibiotics, and wound care

 

 

Sperm granuloma

Pain at the testicular end of the vas or the tail of the epididymis

Asymptomatic: no intervention

Unknown

Occulsion of vas leads to accumulation of sperm

 

Nodule felt during palpation

Pain: use nonsteroidal analgesics

 

 

 

 

Persistent pain: evacuate the cyst; cut and seal the vas ¼ inch toward the testis

 

 

 

 

Do not excise the granuloma

 

 

 

 

Rarely, chronic pain warrants an epididymectomy

 

 

Major complications or mortality are extremely rare, although lethal complications can occur. A single case of lethal gangrene due to group A β-hemolytic streptoccocus is reported in the literature.42 Only 13 major complications were reported in a U.S. survey of more than 65,000 vasectomies for a rate of 0.02%.17

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SEMEN ANALYSIS AND CLEARANCE

Vasectomy success is routinely confirmed by demonstrating the absence of sperm (i.e. azoospermia) in semen samples obtained at one or more clinic visits following the procedure. The time interval to the first follow-up visit is often between 6 and 12 weeks but may be as great as 4 months postvasectomy. Some clinics schedule follow-up based on the number of ejaculations following vasectomy, which may range from 15 to as many as 30 ejaculations prior to obtaining the first follow-up semen analysis.2,41,43,44

There is little consistency in follow-up protocols in terms of when men are told to come for the first semen analysis or the number of azoospermic samples required before clearance is given. Of urologists surveyed in one region of the United States, 85% suggested men return for semen analysis based on time since vasectomy, whereas the remaining 15% based the recommendation on number of ejaculations following vasectomy. Fifteen percent reported that they suggest men return for their first semen analysis at less than 5 weeks postvasectomy, 37% said between 6 and 8 weeks, 33% said after 8 weeks, 5% said after 6 to 10 ejaculations, and 10% said after 11 to 20 ejaculations.45 More recently, a U.S.-wide study has confirmed that this variability exists throughout the country.2

Large variability also exists in the number of azoospermic samples required before clearance. One U.S. study reported that 55% of physicians recommended one sample, 41% recommended two samples, and the remaining 4% recommended between 2 and 10 samples.45 A study by Haws and colleagues2 reported similar variability, with 56% requiring one azoospermic sample, 39% requiring two samples, 5% requiring three samples, and less than 1% requiring four samples.

This large degree of variability in clinical protocols for postvasectomy follow-up reflects the fact that good data regarding time and number of ejaculations to azoospermia following vasectomy are limited. Although there are more than one dozen published studies reporting on semen characteristics postvasectomy, well-designed clinical trials with serial follow-up visits are lacking.

A number of studies have reported the results of time to azoospermia following vasectomy.46–53 Follow-up protocols and procedures, definitions of azoospermia or success, and the way in which results are reported vary widely in these studies. In addition, in some cases, important study details are lacking in the reports. All of these factors make interpretation or generalization of results and comparisons between studies difficult. Reported rates of azoospermia at 6 months range from 48% to 100%.46,47,49,52–56

Relatively little information has been reported in the literature regarding the influence of the number of ejaculations on reaching azoospermia following vasectomy.46,52,57 Reported results are conflicting. Marshal and Lyon46 reported that after 36 ejaculations, all men were azoospermic; Lee57 reported that after 10 ejaculations, 87% of men were azoospermic; and Cortes and colleagues52 reported that after 60 ejaculations, 95 out of 100 men had achieved azoospermia. Lee also noted that after seven ejaculations all men had less than 1 × 106 sperm/ml.57

Several studies have examined changes in sperm function after vasectomy and found a rapid loss of fertilizing competence and sperm motility.58–61 Sperm function was examined by the zona-free hamster oocyte sperm penetration assay by two groups. One reported no penetration with sperm from day 3 postvasectomy, and the other reported that penetration rates with sperm from days 3 to 16 postvasectomy were significantly lower than prevasectomy rates.59,60 Sperm motility was shown to decline rapidly, so that, by days 15 to 19 postvasectomy, all men had 0% sperm motility.58,61 Sivanesaratnam49 reported that at the first postvasectomy visit at 1 month, none of the men had motile sperm. In contrast, Edwards51 reported that some men had motile sperm for up to 9 weeks postvasectomy, and Cortes and colleagues52 found that, although the median time to loss of sperm motility was 3 weeks, the cumulative event rate did not reach its maximum of 90 per 100 men until 15 weeks postvasectomy. Taken together, however, these results suggest that the duration of risk of pregnancy following vasectomy may be considerably shorter than the time necessary to clear all sperm from the reproductive tract.

Many of the current follow-up protocols require that men return for their first semen analysis at long intervals after vasectomy, and during this time an alternative method of contraception must be used. In addition, if azoospermia is not found at the initial visit, additional visits are necessary. Compliance with postvasectomy follow-up has been shown to be poor, with 21% to 45% of men not returning for any follow-up, suggesting that the current follow-up protocols do not work very well.56,62–65

It is possible that azoospermia may not be the best endpoint for vasectomy, and indeed, achievement of azoospermia may not be necessary. As early as 1979 it was suggested that as long as no motile sperm were present, men could rely on their vasectomy for contraception without risk of pregnancy.66 Since then, a number of investigators have suggested alternatives to azoospermia in some cases. Two reports have suggested that “special clearance” should be given in cases in which there are two consecutive counts of less than 10,000 sperm/ml, no motile sperm are present, and it has been at least 7 months since vasectomy.16,67 Edwards51 suggested that testing be done at 4 weeks postvasectomy, and if no motile sperm are present at this point, clearance should be given. Others suggest longer intervals from 12 to 18 weeks.53,68 Data from Chan and coworkers suggest that clearance prior to 18 weeks postvasectomy could lead to missing early recanalizations.53

DeKnijff and coworkers68 comment that men with low numbers of nonmotile sperm are at low risk of producing pregnancy. There are now a number of reports indicating that nonmotile sperm remaining after vasectomy are not associated with pregnancy.16,50,51,66–69 Suggesting that absence of motile sperm be the endpoint for vasectomy is not unreasonable given the fact that sperm motility is required for penetration of cervical mucus70 and for penetration of the oocyte.71 However, at least in the United States, concerns regarding malpractice in cases in which success has been declared without azoospermia and subsequent pregnancy occurs (even if due to recanalization) are likely to affect follow-up recommendations.

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EFFICACY

Overall, vasectomy is highly effective and one of the most reliable contraceptive methods available. Failure rates are commonly quoted to be between 0.2% to 0.4%, but failure rates reported in the literature show broader ranges, and rates as high as 3% to 5% have been reported.30,32,35,72 It is important to recognize the limitations of quoting exact failure rates for vasectomy. There are difficulties in interpreting the published studies on vasectomy efficacy because follow-up has been relatively short-term; most reports in the literature are retrospective reviews of individual physicians' experiences; definitions of failure, length of follow-up, and occlusion methods used vary among studies; and details on follow-up protocols, loss to follow-up rates, or statistical methods are often lacking. Large, welldesigned, long-term studies that describe vasectomy failure rates have not been conducted.

Vasectomy failure may be due to user failure or to failure of the technique itself. User failure occurs when alternate contraception is not used during the period after vasectomy but before all sperm are cleared from the reproductive tract. The most common cause of failure of the vasectomy technique itself is spontaneous recanalization of the vas.44 This occurs when a sperm granuloma forms at the site of the vasectomy and links the two cut ends of the vas, creating passageways for sperm.73,74 Recanalization can occur at anytime after vasectomy and is frequently termed early or late. Early recanalization occurs in the first few months after vasectomy before azoospermia is achieved, when sperm counts begin to rise before they have even fallen to zero. Late recanalization occurs after azoospermia has been demonstrated, when motile sperm reappear in the ejaculate.16,44 Late recanalizations can occur several years after successful vasectomy and are usually only identified when a pregnancy occurs; the actual rate in a large population has never been accurately determined. Other possible but rare causes of failure include occlusion of the wrong structure during the vasectomy procedure or the presence of an extra vas.44

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REGRET

Studies have shown that regret among men is associated with marital instability at the time of vasectomy, young age (younger than 31 years), making the decision to have a vasectomy during a time of financial crisis or related to pregnancy, and having very young or no children at the time of vasectomy.9,10,11,75 Regret is also often the result of client dissatisfaction with adverse health effects caused by or perceived to be caused by the procedure. Risk factors for regret should not be used by providers to restrict access to vasectomy for those in risk groups but rather should be used to identify individuals who may need more extensive counseling. Satisfaction with presterilization counseling has been found to correlate positively with poststerilization satisfaction.6,76

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REFERENCES

1. Ross JA, Frankenberg E: Findings from Two Decades of Family Planning Research, pp. 57–62. New York, Population Council, 1993.

2. Haws JM, Morgan GT, Pollack AE et al: Clinical aspects of vasectomies performed in the United States in 1995. Urology 52: 685, 1998.

3. U.S. Centers for Disease Control and Prevention and AVSC International, unpublished data, 1995.

4. Baumgarten HG, Owman C, Sjoberg NO: Neural mechanisms in male fertility. In Sciarra JJ, Markland C, Speidel JJ (eds): Control of Male Fertility, pp. 26–40. Hagerstown, MD, Harper & Row, 1975.

5. Mumford SD: Vasectomy: The Decision-Making Process. San Francisco, San Francisco Press, 1977.

6. Pollack AE, Carignan C, Pati S: What's new with male sterilization: An update. Contemp Ob/Gyn 43: 41, 1998.

7. Haws JM, Butta PG, Girvin S: A comprehensive and efficient process for counseling patients desiring sterilization. Nurse Pract 22: 52, 1997.

8. Davis LE, Stockton MD: No-scalpel vasectomy. Prim Care 24: 433, 1997.

9. Shain RN: Psychosocial consequences of vasectomy in developed and developing countries. In Zatuchni GI et al (eds): Male Contraception: Advances and Future Prospects, pp. 34–53. Philadelphia, Harper & Row, 1986.

10. Howard G: Who asks for vasectomy reversal and why? BMJ 285: 490, 1982.

11. Kjersgaard AG, Thranov I, Rasmussen OV: Vasectomy: A study of 810 vasectomized men—Who regretted it? Ugeskrift For Laeger 149: 2527, 1987.

12. Butta P: Informed Consent and Voluntary Sterilization: An Implementation Guide for Program Managers, pp. 4–8. New York, AVSC International, 1995.

13. World Health Organization (WHO): Improving Access to Quality Care in Family Planning: Medical Eligibility Criteria for Contraceptive Use, pp. 103–104. Geneva, WHO, 1996.

14. Li SQ, Goldstein M, Zhu J et al: The no-scalpel vasectomy. J Urol 145: 341, 1991.

15. AVSC International. No-Scalpel Vasectomy: An Illustrated Guide for Surgeons, 2nd ed. New York, AVSC International, 1997.

16. Philp T, Guillebaud J, Budd D: Complications of vasectomy: Review of 16,000 patients. Br J Urol 56: 745, 1984.

17. Kendrick JS, Gonzales B, Huber DH et al: Complications of vasectomies in the United States. J Family Pract 253: 245, 1987.

18. Nirapathpongporn A, Huber DH, Krieger JN: No-scalpel vasectomy at the King's birthday vasectomy festival. Lancet 335: 894, 1990.

19. Alderman PM: Complications in a series of 1224 vasectomies. J Fam Pract 33: 579, 1991.

20. Sokal D, McMullen S, Gates D, Dominik R: A comparative study of the no scalpel and standard incision approaches to vasectomy in 5 countries. The Male Sterilization Investigator Team. J Urol 162: 1621, 1999.

21. Arellano LS, Gonzalez Barrera JL, Hernandez Ono A et al: No-scalpel vasectomy: Review of the first 1000 cases in a family medicine unit. Arch Med Res 28: 517, 1997.

22. Skriver M, Skovsgaard F, Miskowiak J: Conventional or Li vasectomy: A questionnaire study. Br J Urol 79: 596, 1997.

23. Hallan RI, May AR: Vasectomy: How much is enough? Br J Urol 62: 377, 1988.

24. Schmidt SS: Vasectomy by section, luminal fulguration and fascial interposition. Br J Urol 76: 373, 1995.

25. Hargreave TB: Vasectomy. In Hargreave TB (ed): Male Infertility, 2nd ed, pp. 365–392. New York, Springer Verlag, 1994.

26. Denniston GC, Kuehl L: Open-ended vasectomy: Approaching the ideal technique. J Am Board Fam Pract 7: 285, 1994.

27. Silber SJ: Sperm granuloma and the reversibility of vasectomy. Lancet 2: 588, 1977.

28. Moss WM: A comparison of open-end versus closed-end vasectomies: A report on 6220 cases. Contraception 46: 521, 1992.

29. Errey BB, Edwards IS: Open-ended vasectomy: An assessment. Fertil Steril 45: 843, 1986.

30. Temmerman M, Cammu H, Devroey P et al: Evaluation of one-hundred open-ended vasectomies. Contraception 33: 529, 1986.

31. Goldstein M: Vasectomy failure using an open-ended technique. Fertil Steril 40: 699, 1983.

32. Shapiro EI, Silber SJ: Open-ended vasectomy, sperm granuloma, and postvasectomy orchialgia. Fertil Steril 32: 546, 1979.

33. Esho JO, Cass AS: Recanalization rate following methods of vasectomy using interposition of fascial sheath of vas deferens. J Urol 120: 178, 1978.

34. Denniston GC: Vasectomy by electrocautery: Outcomes in a series of 2500 patients. J Fam Pract 21: 35, 1985.

35. Li SQ, Xu B, Hou YH et al: Relationship between vas occlusion techniques and recanalization. Adv Contra Del Sys 10: 153, 1994.

36. Appell RA, Evans PR: Vasectomy: Etiology of infectious complications. Fertil Steril 33: 52, 1980.

37. Randall PE, Ganguli LA, Marcuson RW: Wound infection following vasectomy. Br J Urol 55: 564, 1983.

38. Randall PE, Ganguli LA, Kearney MGL et al: Prevention of wound infection following vasectomy. Br J Urol 57: 227, 1985.

39. Peterson, HB, Huber DH, Belker AM: Vasectomy: An appraisal for the obstetrician-gynecologist. Obstet Gynecol 76: 568, 1990.

40. Balough K, Argenyi ZB: Vastis nodosa and spermatic granuloma of the skin: An histologic study of a rare complication of vasectomy. J Cutan Pathol 12: 528, 1985.

41. Rajfer J, Bennett CJ: Vasectomy. Urol Clin North Am 15: 631, 1988.

42. Viddeleer AC, Lycklama a Nijeholt GA: Lethal Fournier's gangrene following vasectomy. Urol 147: 1613, 1992.

43. Schmidt SS: Vasectomy. Urol Clin North Am 14: 149, 1987.

44. Alderman PM: The lurking sperm: A review of failures in 8879 vasectomies performed by one physician. JAMA 259: 3142, 1988.

45. Babayan RK, Krane RJ: Vasectomy: What are community standards? Urol 27: 328, 1986.

46. Marshall S, Lyon RP: Variability of sperm disappearance from the ejaculate after vasectomy. J Urol 107: 815, 1972.

47. Margaret Pyke Center: One thousand vasectomies. BMJ 4:216, 1973.

48. Spencer B, Charlesworth D: Factors determining the rate of disappearance of sperm from the ejaculate after vasectomy. Br J Surg 63: 477, 1976.

49. Sivanesaratnam V: Onset of azoospermia after vasectomy. NZ Med J 98: 778, 1985.

50. Alderman PM: General and anomalous sperm disappearance characteristics found in a large vasectomy series. Fertil Steril 51: 859, 1989.

51. Edwards IS: Earlier testing after vasectomy based on the absence of motile sperm. Fertil Steril 59: 431, 1993.

52. Cortes M, Flick A, Barone MA et al: Results of a pilot study of the time to azoospermia after vasectomy in Mexico City. Contraception 56: 215, 1997.

53. Chan J, Anderson R, Glasier A et al: Post-vasectomy semen analysis: Unnecessary delay or belt and braces? Br J Fam Plann 23: 77, 1997.

54. Matarwood RP, Beral V: Disappearance of spermatozoa from ejaculate after vasectomy. BMJ 13: 87, 1979.

55. Tailly G, Vereecken RL, Verduyn H: A review of 357 bilateral vasectomies for male sterilization. Fertil Steril 14: 424, 1984.

56. Smith AG, Crooks J, Singh NP et al: Is the timing of post-vasectomy seminal analysis important? Br J Urol 81: 458, 1998.

57. Lee HY: Technique and results of vasectomy in Korea. In Sciarra JJ, Markland C, Speidel JJ (eds): Control of Male Fertility, pp. 68–75. Hagerstown, MD, Harper & Row, 1975.

58. Jouannet P, Davis J: Evolution of the properties of semen immediately following vasectomy. Fertil Steril 29: 435, 1978.

59. Lewis EL, Brazil CK, Overstreet JW: Human sperm function in the ejaculate following vasectomy. Fertil Steril 42: 895, 1984.

60. Richardson DW, Aitken RJ, Loudon NB: The functional competence of human spermatozoa recovered after vasectomy. Reprod Fertil 70: 575, 1984.

61. Bedford JM, Zelikovsky G. Viability of spermatozoa in the human ejaculate after vasectomy. Fertil Steril 32: 460, 1979.

62. Smucker DR, Mayhew HE, Nordlund DJ et al: Postvasectomy semen analysis: Why patients don't follow-up. J Am Board Fam Pract 4: 5, 1991.

63. Mumford, SD, Davis JE, Freund M: Considerations in selecting a postvasectomy semen examination regimen. Int Urol Nephrol 14: 293, 1982.

64. Belker AM, Sexter MS, Sweitzer SJ et al: The high rate of noncompliance for post-vasectomy semen examination: Medical and legal considerations. J Urol 144: 284, 1990.

65. Maatman TJ, Aldrin L, Carothers GG: Patient noncompliance after vasectomy. Fertil Steril 68: 552, 1997.

66. Edwards IS, Farlow JL: Non-motile sperms persisting after vasectomy: Do they matter? BMJ 1: 87, 1979.

67. Davies AH, Sharp RJ, Cranston D et al: The long-term outcome following “special clearance” after vasectomy. Br J Urol 66: 211, 1990.

68. DeKnijff DWW, Vrijhof HJEJ, Arends R et al: Persistence or reappearance of nonmotile sperm after vasectomy: Does it have clinical consequences? Fertil Steril 67: 332, 1997.

69. Thompson B, MacGregor JE, MacGillivray et al:Experience with sperm counts following vasectomy. Br J Urol 68: 230, 1991.

70. Mortimer D, Pandya IJ, Sawers RS: Relationship between human sperm motility characteristics and sperm penetration into human cervical mucus in vitro. J Reprod Fertil 78: 93, 1986.

71. Amelar RD, Dubin L, Schoenfeld C: Sperm motility. Fertil Steril 34: 197, 1980.

72. Schmidt SS, Free MJ: The bipolar needle for vasectomy. I. Experience with the first 1000 cases. Fertil Steril 29: 676, 1978.

73. Pugh RC, Hanley HG: Spontaneous recanalisation of the divided vas deferens. Br J Urol 41: 340, 1969.

74. Esho JO, Ireland GW, Cass AS: Recanalization following vasectomy. Urology 3: 211, 1974.

75. Clarke L, Gregson S: Who has a vasectomy reversal? J Biosoc Sci 18: 253, 1986.

76. Ehn BE, Liljestrand J: A long-term follow-up of 108 vasectomized men: Good counselling routines are important. Scand J Urol Nephrol 29: 477, 1995.

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