Cloxacillin (Cloxapen)

Category:

  • Antibiotic

Description:

  • Penicillinase-Resistant Penicillin

Indications:

  • Mild to moderate infections caused by penicillinase-producing staphylococci

  • Upper Respiratory Tract Infections

  • Localized soft tissue/skin infections

  • Lower Respiratory Tract Infections

  • Disseminated infections

Contraindications:

  • None

Precautions:

  • Pregnancy category B

  • Use with caution in patients with penicillin or cephalosporin allergy (5-10% chance of cross-reactivity)

  • Counsel patient to finish all medication to prevent development of resistance

  • Inform patient to take at even intervals, preferably around the clock

  • Take on an empty stomach, 1 hour before or 2 hours after meals.  Food inhibits absorption

Adverse Reactions (Side Effects):

  • Hypersensitivity

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis  

Dosage:

  • Administered orally (capsules and pediatric suspension)

  • Adult and children (>20kg):

    • 250-500mg q6h

  • Child (<20kg):

    • 50-100mg/kg in divided doses q6h

    • oral suspension:  refrigerate, shake well, good for 14 days

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300  

Gynecology and Obstetrics CD-ROM
Volumes 1-6
2004 Edition
 Lippincott Williams & Wilkins
Copyright 2004
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