Iodoquinol (Yodoxin)

Category:

Miscellaneous

Description:

Amebicide

Indications:

Intestinal amebiasis

Contraindications:

Hypersensitivity to iodine, renal disease, hepatic disease
Severe thyroid disease, pre-existing optic neuropathy

Precautions:

Pregnancy category C; excretion into breast milk unknown
Thyroid disease

Adverse Reactions (Side Effects):

CNS: agitation, headache, malaise, peripheral neuropathy
EENT: blurred vision, optic atrophy, optic neuritis, retinal edema, sore throat
GI: abdominal cramps, anal itching, diarrhea, epigastric distress, gastritis, nausea, rectal irritation, vomiting
HEME: agranulocytosis (rare)
SKIN: alopecia, discolored skin, hair, nails; pruritis, rash
MISC: chills, fever, thyroid enlargement, vertigo

Dosage:

Administered orally: Poorly absorbed, excreted in feces

Adult: PO 650mg 3 times daily after meals for 20 days, not to exceed 2g daily
Child: PO 30-40 mg/kg/day in 3 divided doses for 20 days, not to exceed 1.95g in 24 hours for 20 days; do not repeat treatment before 2-3 weeks

Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300