Penicillin G Procaine

Penicillin G Procaine (Wycillin)

Category:

Antibiotic

Description:

Penicillin, Natural

Indications:

Refer to Penicillin G Aqueous monograph

Contraindications:

Never use IV

Precautions:

Pregnancy category B
Use with caution in patients with penicillin or cephalosporin allergy (5-10% chance of cross-reactivity)
Deep intramuscular injection only into the upper, outer quadrant of the buttocks

Adverse Reactions (Side Effects):

Hypersensitivity
Gastrointestinal: nausea, vomiting, diarrhea
Vaginitis

Dosage:

Administered by IM injection ONLY

Pneumococcal infections:
- Adult: 600,000 to 1 million units per day
- Children (<60kg): 300,000 units per day
Streptococcal infections (Group A):
- Adult: 600,000 to 1 million units per day
- Children (<60kg): 300,000 units per day
Bacterial endocarditis:
- Adult: 600,000 to 1 million units per day
Staphylococcal infections:
- Adult: 600,000 to 1 million units per day
- Children (<60kg): 300,000 units per day
Rat-bite fever
- Adult: 600,000 to 1 million units per day
Erysipeloid endocarditis
- Adult: 600,000 to 1 million units per day
Diphtheria
- Adjunct to antitoxin: 300,000-600,000 units per day
- Carrier state: 300,000 units per day for 10 days
Anthrax (cutaneous):
- 600,000 to 1 million units per day for 10 days
Syphilis:
- Primary, secondary and latent: 600,000 units per day for 8 days
- Late (tertiary, neurosyphilis): 600,000 units per day for 10-15 days
- Neurosyphilis: 2.4 million units per day (with probenecid 500mg orally qid) for 10-14 days
- Congenital: 50,000 units/kg/day (one IM dose) for 10 days
Yaws (bejel and pinta):
- treat same as syphilis in corresponding stage of disease
Gonorrheal infections:
- 4.8 million units divided into at least two doses at one visit with 1 gram of probenecid between doses
Vincent’s gingivitis and pharyngitis:
- 600,000 to 1 million units per day

Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300