Erythromycin
Ethylsuccinate and Sulfisoxazole (Pediazole)
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Category:
Description:
Indications:
Contraindications:
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Hypersensitivity
to sulfa-related medications (sulfonylureas, thiazide and loop
diuretics, carbonic anhydrase inhibitors, sunscreens with PABA, local
anesthetics)
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Pregnancy
at term
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Lactation
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Infants
less than 2 months old (except congenital toxoplasmosis as adjunct
with pyrimethamine)
Precautions:
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Pregnancy
category C
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Sulfonamides
have been associated with severe hypersensitivity reactions and death.
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Serious
blood disorders (agranulocytosis, hepatocellular necrosis, aplastic
anemia) have been associated with sulfonamides.
Perform complete blood counts.
Symptoms of sore throat, fever, pallor, purpura or jaundice may
be early signs of serious blood disorders.
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Use
with caution in patients with severe asthma or allergies.
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Hemolytic
anemia may occur in patients with G-6-PD deficiency.
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Photosensitization
may occur, caution patients to use protective measures against
ultraviolet or sunlight until tolerance is determined.
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Sulfonamides
increase the effect of oral anticoagulants (warfarin).
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Take
with a full glass of water and increase fluid intake to 2-3 liters per
day.
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Complete
full course of therapy.
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For
oral suspension; store in refrigerator, shake well before using,
expiration 10 days.
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May
be administered without regard to meals.
Adverse
Reactions (Side Effects):
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Headache,
peripheral neuropathy, depression
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Tinnitis,
vertigo
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Nausea,
emesis, abdominal pain, anorexia, diarrhea
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Hepatitis,
pancreatitis, stomatitis
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Urticaria,
Stevens-Johnson type erythema multiforme
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Crystalluria,
elevated creatinine
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Drug
fever, chills
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Photosensitivity
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Dosage:
Administered
orally (suspension)
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Acute
otitis media:
-
Children
(> 2months):
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Source:
Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
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