Estrogens and Methyltestosterone (Estratest, Estratest H.S.)

Category:

  • Hormonal

Description:

  • Estrogen and Androgen combination hormone replacement

  • Estratest: 1.25mg esterified estrogens, 2.5mg methyltestosterone

  • Estratest H.S.: 0.625mg esterified estrogens, 1.25mg methyltestosterone

Indications:

  • Menopausal vasomotor symptoms (hot flashes, etc.)

  • Postpartum breast engorgement

Contraindications:

  • Known or suspected breast cancer (except those being treated for metastatic disease)

  • Known or suspected estrogen-dependent neoplasia

  • Known or suspected pregnancy

  • Undiagnosed abnormal genital bleeding

  • Current or history of thrombophlebitis, thrombosis, thromboembolic disorders (except when used in breast or prostatic cancer treatment).

Precautions:

  • Pregnancy category X

  • Use with caution in nursing mothers and patients with hypertension, diabetes, asthma, epilepsy, migraine, cardiac or renal dysfunction, history of depression, pre-existing uterine leiomyotoma, history of jaundice during pregnancy, impaired liver function, metabolic bone disorders and in young women (and men).

  • Take with food to avoid GI side effects.

  • May decrease glucose intolerance in diabetic patients.

  • Discontinue therapy and contact health care provider if pregnancy is suspected.

  • Rule out breast cancer prior to initiating treatment.

  • May cause irreversible androgenic effects (hirsutism, decreased breast size, deepening of voice, clitoral hypertrophy)

Adverse Reactions (Side Effects):

  • Rash, acne, alopecia, nausea

  • Abnormal menstrual bleeding, changes in cervical secretions

  • Edema, weight change

  • Depression, insomnia, somnolence

  • Androgenic: acne, oily kin/hair, weight gain, mild hirsutism, decreased breast size, deepening of voice, clitoral hypertrophy, testicular hypotrophy

  • Hypoestrogenic: flushing, sweating, vaginitis, nervousness, emotional disorders

  • Hepatic dysfunction

  • CNS: dizziness, headache, sleep disorders, fatigue

  • Muscle cramps, joint pain and swelling

Dosage:

  • Administered orally

  • Menopausal vasomotor symptoms: 1 tablet per day

  • Postpartum breast engorgement: 1 tablet per day for 5 days

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300  

Gynecology and Obstetrics CD-ROM
Volumes 1-6
2004 Edition
 Lippincott Williams & Wilkins
Copyright 2004
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