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Pathology Atlas: Vagina


Squamous Cell Carcinoma

Squamous cell carcinoma of the vagina (X200 magnification) demonstrating keratin pearl formation.

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Clear Cell Carcinoma

Vaginal clear-cell adenocarcinoma (X200 magnification) from a DES-exposed patient.

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Vaginal Melanoma

Vaginal melanoma (X100 magnification). Junctional melanocytic proliferation and infiltrate of pigmented (epithelioid) melanoma.

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Sarcoma Botryoides

Sarcoma botryoides (X100). Cambium layer beneath epithelium. Loose spindle cell infiltrate. Inset (X400) demonstrates cross-striation in cytoplasm of spindle cells.

Sarcoma botryoides arising from the vagina of a 2-year-old girl, showing the squamous epithelium ( A) and the subepithelial cambium zone ( B ). Notice the central myxoid loose stroma ( C) (× 360)

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